Use of induced pluripotent stem cells to investigate the effects of purine nucleoside phosphorylase deficiency on neuronal development
Abstract
Introduction
Methods
Results
Pluripotency and enzyme deficiency maintained in PNP-deficient iPSC
PNP-deficient iPSC have reduced cell and nucleus size
PNP-deficient iPSC demonstrate enhanced apoptosis
Discussion
Conclusion
Abbreviations
- HSC
- hematopoietic stem cells
- iPSC
- induced pluripotent stem cells
- PNP
- purine nucleoside phsphorylase
- PNP−/−
- PNP-deficient
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