Chronic mucocutaneous candidiasis: a spectrum of genetic disorders
Abstract
Introduction
Candida infection in healthy and immunocompromised individuals
Detection of Candida by immune cells
Monogenic defects causing CMCC
Autoimmune regulator (AIRE) deficiency
Signal transducer and activator of transcription-1 (STAT1) dysfunction
Caspase recruitment domain-containing protein 9 (CARD9) deficiency
Interleukin-17 pathway defects
Signal transducer and activator of transcription-3 (STAT3) dysfunction
Dedicator of cytokinesis 8 (DOCK8) deficiency
Tyrosine Kinase 2 (TYK2) deficiency
CD25 deficiency
Protein tyrosine phosphatase non-receptor type-22 (PTPN22) mutations
Susceptibility genes associated with CMCC
Concluding remarks
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