Autoimmune manifestations following COVID-19 infection in two individuals with primary immunodeficiency
Abstract
Background: Due to widespread vaccination efforts worldwide, the mortality rates linked to COVID-19 have been decreasing. Nevertheless, there persists a notable level of morbidity, marked by increased occurrences of post-COVID-19 conditions. This includes the development of new autoimmune and inflammatory diseases in individuals who have recovered from COVID-19. A more severe progression of COVID-19 has been correlated with an increased probability of newly diagnosed autoimmune disease, and among individuals with pre-existing autoimmune conditions, COVID-19 increased the risk of developing another autoimmune disease.
Methods: Our patients’ medical records were analyzed retrospectively, including their medical history.
Results: We present two cases of primary immunodeficiency patients. One of them experienced the onset of new autoimmune symptoms, while the other had a worsening of her autoimmune condition following COVID-19 infection.
Conclusion: Recognizing the potential connection between COVID-19 and autoimmune conditions is crucial for identifying symptoms promptly in primary immunodeficiency patients and ensuring timely treatment. Further research is required to comprehensively grasp the relationship between COVID-19 and the development of autoimmunity in this particular patient group.
Statement of novelty: In this paper, we present a novel exploration into the emergence of autoimmune manifestations in primary immunodeficiency patients subsequent to COVID-19 infection, through an analysis of two distinct case reports.
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Published In
LymphoSign Journal
Volume 11 • Number 2 • June 2024
Pages: 26 - 31
History
Received: 4 May 2024
Accepted: 21 May 2024
Accepted manuscript online: 27 May 2024
Version of record online: 10 July 2024
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© 2024.
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AzharAl Shaqaq and AbdulrahmanAl Ghamdi. 2024. Autoimmune manifestations following COVID-19 infection in two individuals with primary immunodeficiency. LymphoSign Journal.
11(2): 26-31. https://doi.org/10.14785/lymphosign-2024-0004
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