A protocol for matched unrelated donor hematopoietic stem cell transplantations for severe combined immunodeficiency
Abstract
Hematopoietic stem cell transplantation using HLA-mismatched related donors for the treatment of severe combined immunodeficiency has led to disappointing outcomes at our institution. This created an impetus to consider other donor sources when an HLA-matched related donor was not available. In 1988, a new protocol using HLA-matched unrelated donors was developed at our institution and continues to be used to date. This has contributed to improved outcomes and change in practice for patients with severe combined immunodeficiency.
Statement of novelty: This report describes in detail the protocol for hematopoietic stem cell transplantations using HLA-matched unrelated donors for patients with severe combined immunodeficiency at our institution. This protocol is published for those centres wishing for guidance in setting up procedures for hematopoietic stem cell transplantation.
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Published In
LymphoSign Journal
Volume 3 • Number 1 • March 2016
Pages: 41 - 45
History
Received: 18 December 2015
Accepted: 7 January 2016
Version of record online: 16 March 2016
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Vy Hong-Diep Kim. 2016. A protocol for matched unrelated donor hematopoietic stem cell transplantations for severe combined immunodeficiency. LymphoSign Journal.
3(1): 41-45. https://doi.org/10.14785/lpsn-2015-0015
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1. Matched related donor hematopoietic stem cell transplantation protocol for patients with primary immunodeficiency
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