Open access

Managing newborn screening for SCID in a referral centre

Publication: LymphoSign Journal
29 May 2017

Abstract

Newborn screening for severe combined immunodeficiency was implemented in Ontario in August 2013. Infants identified by a positive newborn screen are referred in an orderly fashion for evaluation by an expert immunologist and, when appropriate, for immune function studies and treatment.
Statement of novelty: We demonstrate a novel flow chart for assessing and referring newborn screen-positive cases.

Formats available

You can view the full content in the following formats:

REFERENCES

Comeau A.M., Hale J.E., Pai S.Y., Bonilla F.A., Notarangelo L.D., Pasternack M.S., Meissner H.C., Cooper E.R., DeMaria A., Sahai I., and Eaton R.B.2010. Guidelines for implementation of population-based newborn screening for severe combined immunodeficiency. J. Inherit. Metab. Dis.33:273–281.
Dalal I., Reid B., Doyle J., Freedman M., Calderwood S., Saunders F., and Roifman C.M.2000. Matched unrelated bone marrow transplantation for combined immunodeficiency. Bone Marrow Transplant.25:613–621.
Douek D.C., McFarland R.D., Keiser P.H., Gage E.A., Massey J.M., Haynes B.F., Polis M.A., Haase A.T., Feinberg M.B., Sullivan J.L., Jamieson B.D., Zack J.A., Picker L.J., and Koup R.A.1998. Changes in thymic function with age and during the treatment of HIV infection. Nature. 396:690–695.
Grunebaum E., Mazzolari E., Porta F., Dallera D., Atkinson A., Reid B., Notarangelo L.D., and Roifman C.M.2006. Bone marrow transplantation for severe combined immune deficiency. JAMA. 295:508–518.
Kobrynski L.2015. Newborn screening for severe combined immune deficiency (technical and political aspects). Curr. Opin. Allergy Clin. Immunol.15:539–546.
Kwan A., Abraham R.S., Currier R., Brower A., Andruszewski K., Abbott J.K., Baker M., Ballow M., Bartoshesky L.E., Bonilla F.A., Brokopp C., Brooks E., Caggana M., Celestin J., Church J.A., Comeau A.M., Connelly J.A., Cowan M.J., Cunningham-Rundles C., Dasu T., Dave N., De La Morena M.T., Duffner U., Fong C.T., Forbes L., Freedenberg D., Gelfand E.W., Hale J.E., Hanson I.C., Hay B.N., Hu D., Infante A., Johnson D., Kapoor N., Kay D.M., Kohn D.B., Lee R., Lehman H., Lin Z., Lorey F., Abdel-Mageed A., Manning A., Mcghee S., Moore T.B., Naides S.J., Notarangelo L.D., Orange J.S., Pai S.Y., Porteus M., Rodriguez R., Romberg N., Routes J., Ruehle M., Rubenstein A., Saavedra-Matiz C.A., Scott G., Scott P.M., Secord E., Seroogy C., Shearer W.T., Siegel S., Silvers S.K., Stiehm E.R., Sugerman R.W., Sullivan J.L., Tanksley S., Tierce M.L.T., Verbsky J., Vogel B., Walker R., Walkovich K., Walter J.E., Wasserman R.L., Watson M.S., Weinberg G.A., Weiner L.B., Wood H., Yates A.B., Puck J.M., and Bonagura V.R.2014. Newborn screening for severe combined immunodeficiency in 11 screening programs in the United States. JAMA. 312:729–738.
Roifman C.M.2017. Primary T-cell immunodeficiencies. In Rich R.R., ed. Clinical immunology principles and practice. 5th ed. Elsevier.
Routes J.M., Grossman W.J., Verbsky J., Laessig R.H., Hoffman G.L., Brokopp C.D., and Baker M.W.2009. Statewide newborn screening for severe T-cell lymphopenia. JAMA. 302:2465–2470.
Vogel B.H., Bonagura V., Weinberg G.A., Ballow M., Isabelle J., Diantonio L., Parker A., Young A., Cunningham-Rundles C., Fong C.T., Celestin J., Lehman H., Rubinstein A., Siegel S., Weiner L., Saavedra-Matiz C., Kay D.M., and Caggana M.2014. Newborn screening for SCID in New York State: Experience from the first two years. J. Clin. Immunol.34:289–303.

Information & Authors

Information

Published In

cover image LymphoSign Journal
LymphoSign Journal
Volume 4Number 2June 2017
Pages: 77 - 79

History

Received: 11 April 2017
Accepted: 18 May 2017
Accepted manuscript online: 29 May 2017

Authors

Affiliations

Brenda Reid [email protected]
Division of Immunology and Allergy, Department of Pediatrics, The Hospital for Sick Children and The University of Toronto, Toronto, ON
Adi Ovadia
Division of Immunology and Allergy, Department of Pediatrics, The Hospital for Sick Children and The University of Toronto, Toronto, ON
The Canadian Centre for Primary Immunodeficiency and The Jeffrey Modell Research Laboratory for the Diagnosis of Primary Immunodeficiency, The Hospital for Sick Children, Toronto, ON
Yael Dinur Schejter
Division of Immunology and Allergy, Department of Pediatrics, The Hospital for Sick Children and The University of Toronto, Toronto, ON
The Canadian Centre for Primary Immunodeficiency and The Jeffrey Modell Research Laboratory for the Diagnosis of Primary Immunodeficiency, The Hospital for Sick Children, Toronto, ON

Metrics & Citations

Metrics

Other Metrics

Citations

Cite As

Export Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

Cited by

1. Management of newborn screening for severe combined immunodeficiency at a quaternary referral centre—an updated algorithm
2. An unusual presentation of DiGeorge syndrome
3. Report of the Canadian Expert Committee on the management of ADA deficiency
4. Abstracts from the Immunodeficiency Canada—7th SCID Symposium, Montreal, QC, 24 October 2019

View Options

View options

PDF

View PDF

Full Text

View Full Text

Get Access

Login options

Check if you access through your login credentials or your institution to get full access on this article.

Subscribe

Click on the button below to subscribe to LymphoSign Journal

Purchase options

Purchase this article to get full access to it.

Restore your content access

Enter your email address to restore your content access:

Note: This functionality works only for purchases done as a guest. If you already have an account, log in to access the content to which you are entitled.

Media

Media

Other

Tables

Share Options

Share

Share the article link

Share on social media