The spectrum of multisystem inflammatory syndrome (MIS-C) in children infected with severe acute respiratory syndrome coronavirus 2
Abstract
Introduction: The impact of SARS-CoV-2 infections in children has generally been described as relatively benign. However, since April 2020, there have been reports of a new multisystem inflammatory illness affecting children and related to COVID-19 termed multisystem inflammatory syndrome in children (MIS-C).
Aim: To describe 3 cases of children diagnosed with MIS-C and discuss the disease spectrum.
Methods: We collected and reviewed data from 3 cases diagnosed with MIS-C admitted to our pediatric ward between October 2020 and January 2021.
Discussion: MIS-C is a newly described disease that spans a spectrum of phenotypes and severity, and while it shares clinical similarities with Kawasaki disease, it has a unique set of epidemiological, laboratory, and prognostic characteristics. In this review, we hope to add to the understanding of this new entity.
Statement of Novelty: This report discusses 3 cases of MIS-C and elaborates on the spectrum and immunology of this entity. Our cases are unique in their relatively wide spectrum and variability. We hope our own experience with MIS-C adds to the accumulating knowledge and understanding of this emerging disease.
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Published In
LymphoSign Journal
Volume 8 • Number 2 • June 2021
Pages: 48 - 54
History
Received: 27 March 2021
Accepted: 3 May 2021
Accepted manuscript online: 11 May 2021
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© 2021.
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AhmadAmer, AdiOvadia, GilaMeirson, DianaTasher, and IlanDalal. 2021. The spectrum of multisystem inflammatory syndrome (MIS-C) in children infected with severe acute respiratory syndrome coronavirus 2. LymphoSign Journal.
8(2): 48-54. https://doi.org/10.14785/lymphosign-2021-0018
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