Impact of prebiotics, probiotics, and gut derived metabolites on host immunity
Abstract
Increasing evidence indicates that gut microorganisms impact multiple aspects of the innate and adaptive mucosal immune system. Current research focuses on the potential of prebiotics (non-digestible fibres that nourish beneficial bacteria) and probiotics (beneficial live bacteria) to promote health, prevent disease, and for use as a treatment strategy for a variety of immune-mediated conditions. The immune modulatory effects of probiotics and prebiotics are strain- or structure-specific and vary with disease state, age, and sex. Prebiotics and live beneficial bacteria, including their metabolic products or soluble mediators, have the ability to affect the composition of the intestinal microbiota. As well, they influence the integrity and functions of intestinal epithelial cells and antigen presenting cells, including dendritic cells and macrophages, by both direct and indirect mechanisms of action.
Statement of novelty: This review serves to highlight select advances related to the impact of prebiotics, probiotics, and gut microbe-derived metabolites on host immune function.
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LymphoSign Journal
Volume 4 • Number 1 • March 2017
Pages: 1 - 24
History
Received: 12 October 2016
Accepted: 12 December 2016
Accepted manuscript online: 22 December 2016
Version of record online: 22 December 2016
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© 2017.
Authors
Competing Interests
Research efforts of the authors are supported by Lallemand Health Solutions (Montreal, Quebec, Canada) and PMS has received honoraria from Abbott Nutrition, Mead Johnson Nutritionals, and Nestlé Nutrition.
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Richard Y.Wu, Michael P.Jeffrey, Kathene C.Johnson-Henry, Julia M.Green-Johnson, and Philip M.Sherman. 2017. Impact of prebiotics, probiotics, and gut derived metabolites on host immunity. LymphoSign Journal.
4(1): 1-24. https://doi.org/10.14785/lymphosign-2016-0012
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